Synthesis of new 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl radicals and 2-substituted-2,5,5-trimethylpyrrolidin-1-yloxyl radicals based α-amino acids

被引：11

作者：

Balog, MR

Kálai, TK

Jekö, J

Steinhoff, HJ

Engelhard, M

Hideg, K

机构：

[1] Univ Pecs, Inst Organ & Med Chem, H-7602 Pecs, Hungary

[2] ICN Hungary Ltd, H-4440 Tiszavasvari, Hungary

[3] Univ Osnabruck, Dept Phys, D-49069 Osnabruck, Germany

[4] Max Planck Inst Mol Physiol, D-44202 Dortmund, Germany

来源：

SYNLETT | 2004年 / 14期

关键词：

amino acids; azides; free-radicals; O'Donnell synthesis; protecting groups;

D O I：

10.1055/s-2004-834806

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unnatural paramagnetic alpha-amino acids with 2,2,5,5-tetramethyl-2.5-dihydro-1H-pyrrol-1-yloxyl-3-yl radical or 2,5,5-trimethylpyrrolidin-1-yloxyl-2-yl radical side-chains, including a lysine mimic azido precursor and their derivatives, are described. The new set of paramagnetic amino acids presented in this work with different (polar. nonpolar. aliphatic, aromatic, etc.) side-chains offers a useful tool for the ESR study of the protein structure and function after incorporation. fulfilling diverse structural requirements.

引用

页码：2591 / 2593

页数：3

共 30 条

[1] Synthesis of new conformationally rigid paramagnetic α-amino acids [J].