When ribosomes go bad: diseases of ribosome biogenesis

被引：139

作者：

Freed, Emily F. ^{[2
]}

Bleichert, Franziska ^{[2
]}

Dutca, Laura M. ^{[3
]}

Baserga, Susan J. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

MOLECULAR BIOSYSTEMS | 2010年 / 6卷 / 03期

关键词：

DIAMOND-BLACKFAN ANEMIA; SMALL NUCLEOLAR RNA; LINKED DYSKERATOSIS-CONGENITA; INDIAN CHILDHOOD CIRRHOSIS; SMALL-SUBUNIT PROCESSOME; OPEN-ANGLE GLAUCOMA; TCOF1; GENE-PRODUCT; PRADER-WILLI; TELOMERASE COMPONENT; ANAUXETIC DYSPLASIA;

D O I：

10.1039/b919670f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of these complexes. However, in the last few decades, a number of diseases of ribosome biogenesis have been discovered. It remains a challenge in the field to elucidate the molecular mechanisms underlying them.

引用

页码：481 / 493

页数：13

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