Tek/Tie2 signaling: New and old partners

被引：36

作者：

Jones, N

Dumont, DJ

机构：

[1] Sunnybrook & Womens Coll Hlth Sci, Div Canc Biol Res, Toronto, ON M4N 3M5, Canada

[2] Toronto Sunnybrook Reg Canc Ctr, Toronto, ON, Canada

[3] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

来源：

CANCER AND METASTASIS REVIEWS | 2000年 / 19卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Tek/Tie2; angiopoietin; angiogenesis; signal transduction;

D O I：

10.1023/A:1026555121511

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A common property amongst angiogenic ligands such as the vascular endothelial growth factors and the angiopoietins is that they can elicit multiple responses depending upon the context of their expression and the presence of other growth factors. Study of the signal transduction pathways initiated by these growth factors provides insight into the molecular and cellular mechanisms that regulate vessel assembly. Key components of signal transduction cascades can then be used as potential targets in angiogenic therapies. This commentary reviews the recent advances into understanding the molecular signaling pathways mediated through the angiopoietin receptor, Tek/Tie2, as well as their effect on the regulation of distinct cellular aspects of angiogenesis.

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收藏

页码：13 / 17

页数：5

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