Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting

被引：91

作者：

Cushing, Emily M. ^{[1
]}

Chi, Xun ^{[1
]}

Sylvers, Kelli L. ^{[1
]}

Shetty, Shwetha K. ^{[1
]}

Potthoff, Matthew J. ^{[2
,3
]}

Davies, Brandon S. J. ^{[1
]}

机构：

[1] Univ Iowa, Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Dept Biochem,Obes Res & Educ Initiat, 169 Newton Rd, Iowa City, IA 52242 USA

[2] Univ Iowa, Carver Coll Med, Dept Pharmacol, 169 Newton Rd, Iowa City, IA 52242 USA

[3] Univ Iowa, Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, 169 Newton Rd, Iowa City, IA 52242 USA

来源：

MOLECULAR METABOLISM | 2017年 / 6卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Plasma triglycerides; Lipoprotein metabolism; Lipolysis; Lipase inhibition; ENDOTHELIAL-CELL TRANSPORTER; ACTIVATED RECEPTOR-GAMMA; LIPOPROTEIN-LIPASE; LIPID-METABOLISM; TARGET GENE; PPAR-ALPHA; ANGPTL4; TISSUE; CHYLOMICRONS; GPIHBP1;

D O I：

10.1016/j.molmet.2017.06.007

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective: Angiopoietin-like 4 (ANGPTL4) is a fasting-induced inhibitor of lipoprotein lipase (LPL) and a regulator of plasma triglyceride metabolism. Here, we examined the kinetics of Angptl4 induction and tested the hypothesis that ANGPTL4 functions physiologically to reduce triglyceride delivery to adipose tissue during nutrient deprivation. Methods: Gene expression, LPL activity, and triglyceride uptake were examined in fasted and fed wild-type and Angptl4 (-/-) mice. Results: Angptl4 was strongly induced early in fasting, and this induction was suppressed in mice with access to food during the light cycle. Fasted Angptl4 (-/-) mice manifested increased LPL activity and triglyceride uptake in adipose tissue compared to wild-type mice. Conclusions: Angptl4 is induced early in fasting to divert uptake of fatty acids and triglycerides away from adipose tissues. (C) 2017 The Authors. Published by Elsevier GmbH.

引用

页码：809 / 818

页数：10

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