Nociceptin/orphanin FQ and drugs of abuse

被引：85

作者：

Ciccocioppo, R ^{[1
]}

Angeletti, S

Panocka, I

Massi, M

机构：

[1] Univ Camerino, Dept Pharmacol Sci & Expt Med, I-62032 Camerino, Italy

[2] Mil Hyg & Epidemiol, Dept Pharmacol & Toxicol, PL-01163 Warsaw, Poland

来源：

PEPTIDES | 2000年 / 21卷 / 07期

关键词：

nociceptin; orphanin FQ; ORL1; receptors; opioids; brain reward system; drug abuse; reward; reinforcement;

D O I：

10.1016/S0196-9781(00)00245-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nociceptin/orphanin FQ (NC) binds with high affinity to the opioid receptor-like 1 (ORL1) receptor. NC has been reported to block opioid-induced supraspinal analgesia, and it has been proposed that it may represent a functional antiopioid peptide in the control of brain nociceptive processes. The wide distribution of NC and of its receptors in the central nervous system suggests, however, that it may be involved in the control of a variety of biologic functions. Increasing evidence indicates that it may influence the rewarding and reinforcing properties of drugs of abuse. NC has been shown to abolish the rewarding properties of ethanol and morphine in the place conditioning paradigm, to reduce ethanol consumption in alcohol-preferring rats and to inhibit stress-induced alcohol-seeking behavior. These findings suggest that drugs directed at central NC receptors may represent an interesting approach to the treatment of ethanol and opiate abuse. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：1071 / 1080

页数：10

共 117 条

[41] DIFFERENTIAL-EFFECTS OF CGS-8216 AND NALTREXONE ON INGESTIONAL BEHAVIOR [J].

KIRKHAM, TC ;

BARBER, DJ ;

HEATH, RW ;

COOPER, SJ .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 26 (01) :145-151

[42]

Koob G F, 1998, Adv Pharmacol, V42, P978

[43] DRUGS OF ABUSE - ANATOMY, PHARMACOLOGY AND FUNCTION OF REWARD PATHWAYS [J].

KOOB, GF .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (05) :177-184

[44] The role of the striatopallidal and extended amygdala systems in drug addiction [J].

Koob, GF .

ADVANCING FROM THE VENTRAL STRIATUM TO THE EXTENDED AMYGDALA: IMPLICATIONS FOR NEUROPSYCHIATRY AND DRUG ABUSE: IN HONOR OF LENNART HEIMER, 1999, 877 :445-460

[45] CELLULAR AND MOLECULAR MECHANISMS OF DRUG-DEPENDENCE [J].

KOOB, GF ;

BLOOM, FE .

SCIENCE, 1988, 242 (4879) :715-723

[46] Neuroscience of addiction [J].

Koob, GF ;

Sanna, PP ;

Bloom, FE .

NEURON, 1998, 21 (03) :467-476

[47] STRATEGIES TO IMPROVE COMPLIANCE WITH NARCOTIC-ANTAGONISTS [J].

KOSTEN, TR ;

KLEBER, HD .

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, 1984, 10 (02) :249-266

[48] Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice [J].

Köster, A ;

Montkowski, A ;

Schulz, S ;

Stübe, EM ;

Knaudt, K ;

Jenck, F ;

Moreau, JL ;

Nothacker, HP ;

Civelli, O ;

Reinscheid, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (18) :10444-10449

[49] Drug dependence: stress and dysregulation of brain reward pathways [J].

Kreek, MJ ;

Koob, GF .

DRUG AND ALCOHOL DEPENDENCE, 1998, 51 (1-2) :23-47

[50] Comparison of the structure-activity relationships of nociceptin and dynorphin A using chimeric peptides [J].

Lapalu, S ;

Moisand, C ;

Mazarguil, H ;

Cambois, G ;

Mollereau, C ;

Meunier, JC .

FEBS LETTERS, 1997, 417 (03) :333-336

← 1 2 3 4 5 6 7 8 9 10 →