Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of deja vu

被引：73

作者：

Tritschler, Felix ^{[1
]}

Huntzinger, Eric ^{[1
]}

Izaurralde, Elisa ^{[1
]}

机构：

[1] Max Planck Inst Dev Biol, Dept Biochem, D-72076 Tubingen, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 05期

关键词：

MESSENGER-RNA DEGRADATION; POLY(A)-BINDING PROTEIN; TRANSLATIONAL REPRESSION; P-BODIES; ARGONAUTE; DOMAIN; IDENTIFICATION; RECOGNITION; REQUIRES; TARGETS;

D O I：

10.1038/nrm2885

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

GW182 proteins have emerged as key components of microRNA (miRNA) silencing complexes in animals. Although the precise molecular function of GW182 proteins is not fully understood, new findings indicate that they act as poly(A)-binding protein (PABP)-interacting proteins (PAIPs) that promote gene silencing, at least in part, by interfering with cytoplasmic PABP1 (PABPC1) function during translation and mRNA stabilization. This recent discovery paves the way for future studies of miRNA silencing mechanisms.

引用

页码：379 / 384

页数：6

共 52 条

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