Multi-tasking on chromatin with the SAGA coactivator complexes

被引：86

作者：

Daniel, Jeremy A. ^{[1
]}

Grant, Patrick A. ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2007年 / 618卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

SAGA; acetyltransferase; deubiquitinase; transcription; histone;

D O I：

10.1016/j.mrfmmm.2006.09.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Over the past 10 years, much progress has been made to understand the roles of the similar, yet distinct yeast SAGA and SLIK coactivator complexes involved in histone post-translational modification and gene regulation. Many different groups have elucidated functions of the SAGA complexes including identification of novel components, which have conferred additional distinct functions. Together, recent studies demonstrate unique attributes of the SAGA coactivator complexes in histone acetylation, methylation, phosphorylation, and deubiquitination. In addition to roles in transcriptional activation with the 19S proteasome regulatory particle, recent evidence also suggests functions for SAGA in elongation and mRNA export. The modular nature of SAGA allows this -1.8MDa complex to organize its functions and carry out multiple roles during transcription, particularly under conditions of cellular stress. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：135 / 148

页数：14

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