Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins

被引：18

作者：

Plater, MJ

Murdoch, AM

Morphy, JR

Rankovic, Z

Rees, DC

机构：

[1] Univ Aberdeen, Dept Chem, Aberdeen AB24 3UE, Scotland

[2] Organon Labs Ltd, Dept Med Chem, Newhouse ML1 5SH, Scotland

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2000年 / 2卷 / 05期

关键词：

D O I：

10.1021/cc000023+

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.

引用

收藏

页码：508 / 512

页数：5

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