Variations in the cellular proliferation of prolactin cells from late pregnancy to lactation in rats

被引：11

作者：

Carretero, J ^{[1
]}

Rubio, M ^{[1
]}

Blanco, E ^{[1
]}

Burks, OJ ^{[1
]}

Torres, JL ^{[1
]}

Hernández, E ^{[1
]}

Bodego, P ^{[1
]}

Riesco, JM ^{[1
]}

Juanes, JA ^{[1
]}

Vázquez, R ^{[1
]}

机构：

[1] Univ Salamanca, Fac Med, Inst Neurosci Castilla & Leon, Dept Anat & Histol Humanas,Lab Neuroendocrinol, Salamanca 37007, Spain

来源：

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2003年 / 185卷 / 02期

关键词：

prolactin cells; cellular proliferation; late pregnancy; lactation;

D O I：

10.1016/S0940-9602(03)80068-7

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Lactation is a physiological process associated with hyperactivity of hypophyseal prolactin-producing cells. It is known that the percentage of these cells is increased during lactation, although there are discrepancies in the reports regarding the mechanisms responsible for increasing the number of prolactin cells. In order to analyse whether this increase is a result of previous proliferation, variations in the proliferation rate of prolactin-positive cells were determined from late pregnancy to lactation in adult female rats by means of observation of the immunohistochemical expression of PCNA as a marker of cellular proliferation. During late pregnancy, a very significant increase in the percentage of proliferating prolactin cells was observed in comparison to non-pregnant females in the proestrus phase (p < 0.01). Although the percentage of prolactin-positive cells after one week of lactation was higher than in non-lactating or in pregnant females (p < 0.01), the proliferation rate was lower than in the other groups studied. In sum, our results suggest that late pregnancy constitutes a preliminary proliferative phase preparatory to the ensuing lactation phase and that endocrine changes in late pregnancy involve the cellular proliferation of hypophyseal prolactin cells in order to prepare the gland for later demands and to prevent proliferative changes from occurring during lactation.

引用

页码：97 / 101

页数：5

共 25 条

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