Novel cofactors via post-translational modifications of enzyme active sites

被引：91

作者：

Okeley, NM ^{[1
]}

van der Donk, WA ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

CHEMISTRY & BIOLOGY | 2000年 / 7卷 / 07期

关键词：

D O I：

10.1016/S1074-5521(00)00140-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent crystallographic and biochemical studies have revealed the existence of numerous novel post-translational modifications within enzyme active sites. These modifications create structural and functional diversity. Although the function and biosynthesis of some of these modifications are well understood, others need further investigation.

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页码：R159 / R171

页数：13

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共 79 条

[1] Reconstitution of Cu2+-depleted bovine serum amine oxidase with Co2+ [J].

Agostinelli, E ;

De Matteis, G ;

Mondovi, B ;

Morpurgo, L .

BIOCHEMICAL JOURNAL, 1998, 330 :383-387

[2] 3-DIMENSIONAL STRUCTURE OF THE BINUCLEAR METAL CENTER OF PHOSPHOTRIESTERASE [J].

BENNING, MM ;

KUO, JM ;

RAUSHEL, FM ;

HOLDEN, HM .

BIOCHEMISTRY, 1995, 34 (25) :7973-7978

[3] Structure of a human lysosomal sulfatase [J].

Bond, CS ;

Clements, PR ;

Ashby, SJ ;

Collyer, CA ;

Harrop, SJ ;

Hopwood, JJ ;

Guss, JM .

STRUCTURE, 1997, 5 (02) :277-289

[4] Identification of a novel bond between a histidine and the essential tyrosine in catalase HPII of Escherichia coli [J].

Bravo, J ;

Fita, I ;

Ferrer, JC ;

Ens, W ;

Hillar, A ;

Switala, J ;

Loewen, PC .

PROTEIN SCIENCE, 1997, 6 (05) :1016-1023

[5] COMPLETE AMINO-ACID-SEQUENCE OF PROTEUS-MIRABILIS PR CATALASE - OCCURRENCE OF A METHIONINE SULFONE IN THE CLOSE PROXIMITY OF THE ACTIVE-SITE [J].

BUZY, A ;

BRACCHI, V ;

STERJIADES, R ;

CHROBOCZEK, J ;

THIBAULT, P ;

GAGNON, J ;

JOUVE, HM ;

HUDRYCLERGEON, G .

JOURNAL OF PROTEIN CHEMISTRY, 1995, 14 (02) :59-72

[6]

CAI DY, 1994, J BIOL CHEM, V269, P32039

[7] CRYSTALLOGRAPHIC INVESTIGATIONS OF THE TRYPTOPHAN-DERIVED COFACTOR IN THE QUINOPROTEIN METHYLAMINE DEHYDROGENASE [J].

CHEN, LY ;

MATHEWS, FS ;

DAVIDSON, VL ;

HUIZINGA, EG ;

VELLIEUX, FMD ;

DUINE, JA ;

HOL, WGJ .

FEBS LETTERS, 1991, 287 (1-2) :163-166

[8] STRUCTURE OF AN ELECTRON-TRANSFER COMPLEX - METHYLAMINE DEHYDROGENASE, AMICYANIN, AND CYTOCHROME-C(551I) [J].

CHEN, LY ;

DURLEY, RCE ;

MATHEWS, FS ;

DAVIDSON, VL .

SCIENCE, 1994, 264 (5155) :86-90

[9] Refined crystal structure of methylamine dehydrogenase from paracoccus denitrificans at 1.75 Å resolution [J].

Chen, LY ;

Doi, N ;

Durley, RCE ;

Chistoserdov, AY ;

Lidstrom, ME ;

Davidson, VL ;

Mathews, FS .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 276 (01) :131-149

[10] Protein-sulfenic acids: Diverse roles for an unlikely player in enzyme catalysis and redox regulation [J].

Claiborne, A ;

Yeh, JI ;

Mallett, TC ;

Luba, J ;

Crane, EJ ;

Charrier, V ;

Parsonage, D .

BIOCHEMISTRY, 1999, 38 (47) :15407-15416

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