Cu-free click cycloaddition reactions in chemical biology

被引：1344

作者：

Jewett, John C. ^{[1
]}

Bertozzi, Carolyn R. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[4] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2010年 / 39卷 / 04期

关键词：

AZIDE-ALKYNE CYCLOADDITION; FREE TRIAZOLE FORMATION; COPPER-FREE; 1,3-DIPOLAR CYCLOADDITIONS; TERMINAL ALKYNES; LIVING CELLS; CANCER-CELLS; CHEMISTRY; LIGATION; BIOCONJUGATION;

D O I：

10.1039/b901970g

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems-in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.

引用

页码：1272 / 1279

页数：8

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