A comparative study of zinc, magnesium, strontium-incorporated hydroxyapatite-coated titanium implants for osseointegration of osteopenic rats

被引：132

作者：

Tao, Zhou-Shan ^{[1
]}

Zhou, Wan-Shu ^{[2
]}

He, Xing-Wen ^{[3
]}

Liu, Wei ^{[4
]}

Bai, Bing-Li ^{[1
]}

Zhou, Qiang ^{[1
]}

Huang, Zheng-Liang ^{[1
]}

Tu, Kai-kai ^{[1
]}

Li, Hang ^{[1
]}

Sun, Tao ^{[1
]}

Lv, Yang-Xun ^{[5
]}

Cui, Wei ^{[6
]}

Yang, Lei ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, 109 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China

[2] Guizhou Med Univ, Affiliated Hosp, Endocrine & Metab Dis Unit, Guizhou 550001, Peoples R China

[3] Hangzhou Bay Hosp Ningbo, Dept Orthopaed Surg, Hangzhou 315000, Zhejiang, Peoples R China

[4] Jingmen 1 Peoples Hosp, Dept Orthopaed Surg, Jingmen 44800, Hubei, Peoples R China

[5] Wenzhou Cent Hosp, Dept Orthopaed Surg, Wenzhou 325000, Zhejiang, Peoples R China

[6] Sichuan Prov Orthoped Hosp, 132 West First Sect First Ring Rd, Chengdu 610000, Sichuan, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 62卷

基金：

浙江省自然科学基金;

关键词：

Osteoporosis; Implants; Zinc; Magnesium; Strontium; PARATHYROID-HORMONE; 1-34; BETA-TRICALCIUM PHOSPHATE; BONE; RANELATE; DIFFERENTIATION; INTEGRATION; INHIBITION; FIXATION; FEMUR; CELLS;

D O I：

10.1016/j.msec.2016.01.034

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for the implants in cementless arthroplasty. However, its effect is not sufficient for osteoporotic bone. Zinc (Zn), magnesium (Mg), and strontium (Sr) present a beneficial effect on bone growth, and positively affect bone regeneration. The aim of this study was to confirm the different effects of the fixation strength of Zn, Mg, Sr-substituted hydroxyapatite-coated (Zn-HA-coated, Mg-HA-coated, Sr-HA-coated) titanium implants via electrochemical deposition in the osteoporotic condition. Female Sprague-Dawley rats were used for this study. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into four groups: group HA; group Zn-HA; group Mg-HA and group Sr-HA. Afterwards, all rats from groups HA, Zn-HA, Mg-HA and Sr HA received implants with hydroxyapatite containing 0%, 10% Zn ions, 10% Mg ions, and 10% Sr ions. Implants were inserted bilaterally in all animals until death at 12 weeks. The bilateral femurs of rats were harvested for evaluation. All treatment groups increased new bone formation around the surface of titanium rods and push out force; group Sr-HA showed the strongest effects on new bone formation and biomechanical strength. Additionally, there are significant differences in bone formation and push-out force was observed between groups ZnHA and Mg-HA. This finding suggests that Zn, Mg, Sr-substituted hydroxyapatite coatings can improve implant osseointegration, and the 10% Sr coating exhibited the best properties for implant osseointegration among the tested coatings in osteoporosis rats. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：226 / 232

页数：7

共 36 条

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