Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells

被引：129

作者：

Jordan, I

Briese, T

Fischer, N

Lau, JYN

Lipkin, WI

机构：

[1] Univ Calif Irvine, Emerging Dis Lab, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA

[4] ICN Pharmaceut, Costa Mesa, CA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2000年 / 182卷 / 04期

关键词：

D O I：

10.1086/315847

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

West Nile virus (WNV) is an emerging mosquito-borne pathogen that was reported for the first time in the Western hemisphere in August 1999, when an encephalitis outbreak in New York City resulted in 62 clinical cases and 7 deaths. WNV, for which no antiviral therapy has been described, was recently recovered from a pool of mosquitoes collected in New York City. In anticipation of the recurrence of WNV during the summer of 2000, an analysis was made of the efficacy of the nucleoside analogue ribavirin, a broad-spectrum antiviral compound with activity against several RNA viruses, for treatment of WNV infection, High doses of ribavirin were found to inhibit WNV replication and cytopathogenicity in human neural cells in vitro.

引用

页码：1214 / 1217

页数：4

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