Stereocontrolled synthesis of dithymidine phosphorothioates by use of a functionalized 5′-protecting group bearing an imidazole residue

被引：13

作者：

Wada, T ^{[1
]}

Kobayashi, N ^{[1
]}

Mori, T ^{[1
]}

Sekine, M ^{[1
]}

机构：

[1] Tokyo Inst Technol, Fac Biosci & Biotechnol, Dept Life Sci, Midori Ku, Yokohama, Kanagawa 226, Japan

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 1-3期

关键词：

D O I：

10.1080/07328319808005183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diastereoselective formation of internucleotidic phosphorothioate triester bonds was achieved by use of 3-(imidazol-1-ylmethyl)-4',4 "-dimethoxy (IDTr) as a 5'-hydroxyl protecting group in the phosphotriester approach. After removal of all the protecting groups, stereochemistry of the major product was determined as the Sp-configuration by enzymatic digestion.

引用

页码：351 / 364

页数：14

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