Target Volume Delineation for Preoperative Radiotherapy of Rectal Cancer: Inter-Observer Variability and Potential Impact of FDG-PET/CT Imaging

被引：26

作者：

Krengli, Marco ^{[1
]}

Cannillo, Barbara ^{[1
]}

Turri, Lucia ^{[1
]}

Bagnasacco, Paolo ^{[2
]}

Berretta, Laura ^{[3
]}

Ferrara, Teresa ^{[4
]}

Galliano, Mario ^{[5
]}

Gribaudo, Sergio ^{[6
]}

Melano, Antonella ^{[7
]}

Munoz, Fernando ^{[8
]}

Sciacero, Piera ^{[9
]}

Tseroni, Vassiliki ^{[10
]}

Bassi, Maria Chiara ^{[1
]}

Brambilla, Marco ^{[1
]}

Inglese, Eugenio ^{[1
]}

机构：

[1] Univ Hosp Maggiore della Carita, I-28100 Novara, Italy

[2] Hosp Infermi, Biella, Italy

[3] Hosp SS Antonio & Biagio, Alessandria, Italy

[4] Inst Canc Res & Treatment, Turin, Italy

[5] Hosp Cardinal Massaia, Asti, Italy

[6] St Anna Hosp, Turin, Italy

[7] Hosp Santa Croce & Carle, Cuneo, Italy

[8] Univ Hosp San Giovanni Battista, Turin, Italy

[9] Hosp ASL 9, Ivrea, Italy

[10] Hosp San Giovanni Antica Sede, Turin, Italy

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2010年 / 9卷 / 04期

关键词：

Observer variability; PET/CT; Rectal Cancer; Radiotherapy; Treatment planning; POSITRON-EMISSION-TOMOGRAPHY; SEGMENTATION;

D O I：

10.1177/153303461000900408

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To analyze the inter-observer variability and the potential impact of F-18-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) imaging for target volume delineation in preoperative radiotherapy of rectal cancer. Gross tumor volume (GTV) and clinical target volume (CTV) in 2 cases of rectal cancer were contoured by 10 radiation oncologists, 5 on CT and 5 on PET/CT images. Resulting volumes were analyzed by coefficient of variation (CV) and concordance index (CI). Mean GTV was 120 cc +/- 20.4 cc in case A and 119 cc +/- 35.7 cc in case B. Mean CTV was 723 cc +/- 147.5 cc in case A and 739 cc +/- 195.6 cc in case B. CV was lower and CI was similar or higher across the observers contouring GTV on PET/CT. CTV variability was less influenced by the use of PET/CT. PET/CT may allow reducing inter-observer variability in GTV delineation.

引用

页码：393 / 398

页数：6

共 25 条

[1] Staging of primary colorectal carcinomas with fluorine-18 fluorodeoxyglucose whole-body PET: Correlation with histopathologic and CT findings [J].

Abdel-Nabi, H ;

Doerr, RJ ;

Lamonica, DM ;

Cronin, VR ;

Galantowicz, P ;

Carbone, GM ;

Spaulding, MB .

RADIOLOGY, 1998, 206 (03) :755-760

[2] FDG-PET/CT imaging for staging and target volume delineation in preoperative conformal radiotherapy of rectal cancer [J].

Bassi, Maria Chiara ;

Turri, Lucia ;

Sacchetti, Gianmauro ;

Loi, Gianfranco ;

Cannillo, Barbara ;

La Mattina, Pierdaniele ;

Brambilla, Marco ;

Inglese, Eugenio ;

Krengli, Marco .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 70 (05) :1423-1426

[3] Threshold segmentation for PET target volume delineation in radiation treatment planning: The role of target-to-background ratio and target size [J].

Brambilla, M. ;

Matheoud, R. ;

Secco, C. ;

Loi, G. ;

Krengli, M. ;

Inglese, E. .

MEDICAL PHYSICS, 2008, 35 (04) :1207-1213

[4] 18F-FDG positron emission tomography staging and restaging in rectal cancer treated with preoperative chemoradiation [J].

Calvo, FA ;

Domper, M ;

Matute, R ;

Martínez-Lázaro, R ;

Arranz, JA ;

Desco, M ;

Alvarez, E ;

Carreras, JL .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 58 (02) :528-535

[5] THE ROLE OF DUAL-TIME COMBINED 18-FLUORIDEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY IN THE STAGING AND RESTAGING WORKUP OF LOCALLY ADVANCED RECTAL CANCER, TREATED WITH PREOPERATIVE CHEMORADIATION THERAPY AND RADICAL SURGERY [J].

Capirci, Carlo ;

Rubello, Domenico ;

Pasini, Felice ;

Galeotti, Fabrizio ;

Bianchini, Enzo ;

Del Favero, Giuseppe ;

Panzavolta, Riccardo ;

Crepaldi, Giorgio ;

Rampin, Lucia ;

Facci, Enzo ;

Gava, Marcello ;

Banti, Elena ;

Marano, Gianfranco .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 74 (05) :1461-1469

[6] Automated functional image-guided radiation treatment planning for rectal cancer [J].

Ciernik, IF ;

Huser, M ;

Burger, C ;

Davis, JB ;

Szekely, G .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 62 (03) :893-900

[7] Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT):: A feasibility study [J].

Ciernik, IF ;

Dizendorf, E ;

Baumert, BG ;

Reiner, B ;

Burger, C ;

Davis, JB ;

Lütolf, UM ;

Steinert, HC ;

Von Schulthess, GK .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 57 (03) :853-863

[8]

*CTR RIF EP PREV O, 2001, TUM COL RETT LIN GUI

[9]

Erdi YE, 1997, CANCER, V80, P2505, DOI 10.1002/(SICI)1097-0142(19971215)80:12+<2505::AID-CNCR24>3.0.CO

[10]

2-F

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