Cytotoxic and antiplatelet aggregation principles of Ruta graveolens

被引：71

作者：

Wu, TS ^{[1
]}

Shi, LS

Wang, JJ

Iou, SC

Chang, HC

Chen, YP

Kuo, YH

Chang, YL

Teng, CM

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[2] Chi Mei Fdn Hosp, Dept Med Res, Tainan, Taiwan

[3] Brion Res Inst Taiwan, Taipei, Taiwan

[4] Natl Res Inst Chinese Med, Taipei, Taiwan

[5] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2003年 / 50卷 / 01期

关键词：

Ruta graveolens; Rutaceae; structure elucidation; antiplatelet aggregation activity; cytotoxicity;

D O I：

10.1002/jccs.200300024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nineteen compounds have been isolated from the methanol extract of the root and aerial parts of Ruta graveolens. The structural elucidation of these isolated compounds were determined by the spectroscopic methods and/or comparison of the physical data with literature values. Their antiplatelet aggregation and cytotoxic activities were examined to find potent antiplatelet aggregation and cytotoxic compounds from natural resources. Among them, dictamine (5), skimmianine (7), psoralen (8), chalepensin (12), clausindin (13), and graveolinine (16) showed significant inhibition of platelet aggregation, induced by arachidonic acid and collagen. Arborinine (2), dictamine (5), isopimpinellin (11), clausindin (13), and graveoline (17) exhibited cytotoxic activity against KB, Hela, DLD, NCl and Hepa tumor cell lines.

引用

页码：171 / 178

页数：8

共 21 条

[1] Pyranoquinolones and acridones from Vepris bilocularis [J].