Iron homeostasis and inherited iron overload disorders: an overview

被引：33

作者：

Heeney, MM

Andrews, NC

机构：

[1] Childrens Hosp, Div Hematol Oncol, Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Cambridge, MA 02138 USA

[3] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2004年 / 18卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.hoc.2004.06.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Iron is an ubiquitous metal of vital importance to the normal physiologic processes of many organisms. Recent discoveries of mutations in genes that lead to inherited iron overload diseases have advanced the understanding of iron homeostasis in humans. This article provides an overview of the human iron cycle, regulation of iron homeostasis, how perturbations in this homeostasis lead to iron overload disease in adults and children, and strategies for diagnosis of inherited iron overload.

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页码：1379 / +

页数：26

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