Electrochemical behavior of β2-agonists at graphite nanosheet modified electrodes

In this paper, the voltammetric characteristics of several beta(2)-agonists including salbutamol, ractopamine, bamethane, isoxsuprine, ritodrine, fenoterol, terbutaline, metaproterenol, clenbuterol, clenproperol, mabuterol, cimaterol, cimbuterol and brombuterol were comparatively evaluated using graphite nanosheet (GN) modified glassy carbon (GC) electrodes. All the compounds can be oxidized at GN modified electrodes with enhanced peak current and reduced peak potential compared with naked GC electrodes. The electrochemical behaviors of the compounds are different due to different substituent groups on the aromatic rings. For the first time, an ECE process was observed for salbutamol and its analogues. The capability of determining beta(2)-agonists individually or simultaneously from aqueous solution using differential pulse voltammetry and amperometry with the developed electrode was also investigated. (C) 2010 Elsevier B.V. All rights reserved.