Prophylactic effect of dietary seaweed fucoidan against enteral prion infection

被引：25

作者：

Doh-ura, Katsumi

Kuge, Tomoko

Uomoto, Miyuki

Nishizawa, Keiko

Kawasaki, Yuri

Iha, Masahiko

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Prion Res, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Neuropathol, Fukuoka 812, Japan

[3] S Prod Ltd, Okinawa, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期

关键词：

D O I：

10.1128/AAC.00917-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.

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收藏

页码：2274 / 2277

页数：4

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