The DNA damage response: sensing and signaling

被引：153

作者：

McGowan, CH

Russell, P

机构：

[1] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2004.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The protein kinases ATM and ATR are central components of the checkpoint mechanisms that signal the presence of damaged DNA and stalled replication forks. Recent studies have provided important new insights into how these kinases work together with their regulatory subunits, DNA repair proteins and adaptor proteins to sense abnormal DNA structures and implement the appropriate DNA damage response. These advances have provided a more detailed understanding of the interface between damaged DNA and the checkpoint sensor proteins.

引用

收藏

页码：629 / 633

页数：5

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