TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

被引：283

作者：

Pan, GH

Ni, J

Yu, GL

Wei, YF

Dixit, VM

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Human Genome Sci, Rockville, MD 20850 USA

来源：

FEBS LETTERS | 1998年 / 424卷 / 1-2期

关键词：

tumor necrosis factor receptor; TRAIL receptor; apoptosis; death domain; decoy receptor;

D O I：

10.1016/S0014-5793(98)00135-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TRAIL/Apo-2L induces rapid apoptosis of a variety of tumor cell lines. A family of tumor necrosis factor receptor-related molecules have been identified as receptors for TRAIL. Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues. TRUNDD is highly homologous to all known TRAIL receptors and has an extracellular TRAIL-binding domain but lacks a functional intracellular death domain and does not induce apoptosis. Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells. (C) 1998 Federation of European Biochemical Societies.

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页码：41 / 45

页数：5

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