Local renin-angiotensin system in the pineal gland

被引:39
作者
Baltatu, O
Lippoldt, A
Hansson, A
Ganten, D
Bader, M
机构
[1] Max Delbruck Ctr Mol Med, D-13122 Berlin, Germany
[2] Free Univ Berlin, Inst Clin Pharmacol, D-12200 Berlin, Germany
来源
MOLECULAR BRAIN RESEARCH | 1998年 / 54卷 / 02期
关键词
brain; pineal gland; angiotensinogen; angiotensin II receptor; renin; ACE; renin-angiotensin system;
D O I
10.1016/S0169-328X(97)00339-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Besides the classical endocrine renin-angiotensin system (RAS), a local RAS has been described also in the brain. We attempted to clarify the existence of a local RAS in the pineal gland. Through the use of a ribonuclease protection assay, it proved possible to detect the mRNA for angiotensinogen (AOGEN), for the angiotensin receptor type 1A (AT(1a)) and 1B (AT(1b)) and for the angiotensin-converting enzyme (ACE) in pineal glands from rats. Renin mRNA, however, could not be found by this method. By in situ hybridization and immunocytochemistry, AOGEN mRNA was co-localized with the astrocyte marker glial fibrillary acidic protein. AT(1b) mRNA expression exceeded the expression of AT(1a) mRNA and was co-localized with the pinealocyte-specific tryptophan hydroxylase. Thus, in the mammalian pineal gland there is a local formation of the components of the RAS. The presence of angiotensin II receptors further substantiates a role for angiotensins and the pineal RAS in the physiology of this gland. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:237 / 242
页数:6
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