Protein kinases linked to the pathogenesis of Parkinson's disease

被引：45

作者：

Shen, J ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

NEURON | 2004年 / 44卷 / 04期

关键词：

D O I：

10.1016/j.neuron.2004.11.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two papers (by Paisan-Ruiz et al. and by Zimprich et al.) in this issue of Neuron identify a causative gene, LRRK2, for familial parkinsonism. Several dominantly inherited missense mutations have been identified in a number of families that exhibit a broad spectrum of neuropathological features, including deposition of alpha-synuclein and tau proteins. The LRRK2 gene is predicted to encode a large protein containing leucine-rich repeats and Ras/GTPase, tyrosine kinase-like, and WD40 domains.

引用

页码：575 / 577

页数：3

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