Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons

被引：18

作者：

De Giorgio, R

Arakawa, J

Wetmore, CJ

Sternini, C

机构：

[1] Univ Bologna, Dept Internal Med & Gastroenterol, Bologna, Italy

[2] Univ Calif Los Angeles, CURE Digest Dis Res Ctr, Div Digest Dis, Dept Med, Los Angeles, CA 90073 USA

[3] Univ Calif Los Angeles, CURE Digest Dis Res Ctr, Div Digest Dis, Dept Neurobiol, Los Angeles, CA 90073 USA

[4] Vet Adm Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA

[5] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

来源：

PEPTIDES | 2000年 / 21卷 / 09期

关键词：

nerve growth factor; neurotrophins; tyrosine kinase receptor; peptide-containing neurons; enteric nervous system;

D O I：

10.1016/S0196-9781(00)00286-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance P or related tachykinin (SP/TK). Neurotrophin receptors visualized by pan-trk immunoreactivity were found in numerous ganglion cells of both plexuses and in nerve processes in the intestinal wall. Pan-trk submucosal neurons contained VIP (36%) or SP/TK-IR (47%). Pan-trk myenteric neurons contained VIP-IR (57%) or SP/TK (27%). Our data suggest that neurotrophin-3 and neurotrophin receptors may be involved in the maintenance of enteric neuronal circuits, transmission and phenotypic expression. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：1421 / 1426

页数：6

共 43 条

[1] THE TRK FAMILY OF NEUROTROPHIN RECEPTORS [J].