Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer

被引：68

作者：

Abnet, Christian C. ^{[1
]}

Chen, Yu ^{[3
,5
,6
]}

Chow, Wong-Ho ^{[1
]}

Gao, Yu-Tang ^{[8
]}

Helzlsouer, Kathy J. ^{[13
,14
]}

Le Marchand, Loic ^{[10
]}

McCullough, Marjorie L. ^{[7
]}

Shikany, James M. ^{[9
]}

Virtamo, Jarmo ^{[2
]}

Weinstein, Stephanie J. ^{[1
]}

Xiang, Yong-Bing ^{[8
]}

Yu, Kai ^{[1
]}

Zheng, Wei ^{[15
]}

Albanes, Demetrius ^{[1
]}

Arslan, Alan A. ^{[3
,4
,6
]}

Campbell, David S. ^{[12
]}

Campbell, Peter T. ^{[7
]}

Hayes, Richard B. ^{[3
,6
]}

Horst, Ronald L. ^{[11
]}

Kolonel, Laurence N. ^{[10
]}

Nomura, Abraham M. Y. ^{[10
]}

Purdue, Mark P. ^{[1
]}

Snyder, Kirk ^{[12
]}

Shu, Xiao-Ou ^{[15
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20852 USA

[2] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[3] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[4] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA

[5] NYU, Sch Med, Dept Med, New York, NY USA

[6] NYU, Inst Canc, New York, NY USA

[7] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[8] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[9] Univ Alabama, Dept Prevent Med, Birmingham, AL USA

[10] Univ Hawaii, Canc Res Ctr Hawaii, Program Epidemiol, Honolulu, HI 96813 USA

[11] Heartland Assays Inc, Ames, IA USA

[12] Informat Management Serv Inc, Silver Spring, MD USA

[13] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[14] Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA

[15] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Div Epidemiol,Dept Med, Nashville, TN 37212 USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 01期

基金：

美国国家卫生研究院;

关键词：

case-control studies; cohort studies; esophageal neoplasms; prospective studies; stomach neoplasms; vitamin D; VITAMIN-D STATUS; MORTALITY; US;

D O I：

10.1093/aje/kwq121

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw-matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (< 25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference: 50-< 75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91; P trend = 0.003). Never smokers with concentrations of < 25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55, 95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers.

引用

页码：94 / 106

页数：13

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