Plakevulin A, a new oxylipin inhibiting DNA polymerases α and γ from sponge Plakortis species

被引：26

作者：

Tsuda, M

Endo, T

Perpelescu, M

Yoshida, S

Watanabe, K

Fromont, J

Mikami, Y

Kobayashi, J

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

[2] Nagoya Univ, Sch Med, Dis Mechanism & Control Res Inst, Nagoya, Aichi 4668550, Japan

[3] Hokkaido Univ, Fac Agr, Sapporo, Hokkaido 0608589, Japan

[4] Western Australian Museum, Perth, WA 6000, Australia

[5] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chiba 2600856, Japan

来源：

TETRAHEDRON | 2003年 / 59卷 / 08期

关键词：

plakevulin A; DNA polymerase; Mosher's method;

D O I：

10.1016/S0040-4020(03)00045-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new cytotoxic oxylipin, plakevulin A (1), possessing a cyclopentene ring and a levulinyl ester has been isolated from an Okinawan marine sponge Plakortis sp. The structure was elucidated on the basis of spectroscopic data, and the absolute configurations at three chiral centers were assigned by spectroscopic data of the reductive product of 1 and a modified Mosher's method. Plakevulin A (1) exhibited inhibitory activity against DNA polymerases alpha and gamma. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1137 / 1141

页数：5

共 17 条

[11] Novel phenalenone derivatives from a marine-derived fungus exhibit distinct inhibition spectra against eukaryotic DNA polymerases [J].