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Amyloidosis and Alzheimer's disease

被引：153
作者：
Ghiso, J [1 ]
Frangione, B [1 ]
机构：
[1] NYU, Sch Med, Dept Pathol & Psychiat, New York, NY 10016 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2002年 / 54卷 / 12期
关键词：
dementia; neurodegeneration; A beta; paired helical filaments; fibrillogenesis; familial Alzheimer's disease; A beta PP;
D O I：
10.1016/S0169-409X(02)00149-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Alzheimer's disease (AD) is the most frequent type of amyloidosis in humans and the commonest form of dementia. Extracellular Abeta amyloid deposits in the form of amyloid plaques and cerebral amyloid angiopathy as well as intraneuronal neurofibrillary tangles co-exist in the brain parenchyma of AD patients, the cognitive areas being the most severely affected. This review focuses on the potential role of amyloid in the development of neurodegeneration and presents studies of AD and other unrelated inherited dementia syndromes associated with neuronal loss and amyloid deposition in the brain. (C) 2002 Elsevier Science B.V. All rights reserved.
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收藏
页码：1539 / 1551
页数：13
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