Post-translational modifications in signal integration

被引：624

作者：

Deribe, Yonathan Lissanu ^{[2
,3
]}

Pawson, Tony ^{[1
]}

Dikic, Ivan ^{[2
,3
]}

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Ctr Syst Biol, Toronto, ON M5G 1X5, Canada

[2] Goethe Univ Frankfurt, Frankfurt Inst Mol Life Sci, Frankfurt, Germany

[3] Goethe Univ Frankfurt, Inst Biochem 2, Frankfurt, Germany

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2010年 / 17卷 / 06期

关键词：

GROWTH-FACTOR RECEPTOR; UBIQUITIN-BINDING DOMAINS; KAPPA-B ACTIVATION; DNA-DAMAGE; PROTEIN-KINASE; LYSINE ACETYLATION; PROLINE HYDROXYLATION; TRANSLESION SYNTHESIS; CONJUGATING ENZYME; TYROSINE KINASES;

D O I：

10.1038/nsmb.1842

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.

引用

页码：666 / 672

页数：7

共 99 条

[1] The Chk2 protein kinase [J].

Ahn, J ;

Urist, M ;

Prives, C .

DNA REPAIR, 2004, 3 (8-9) :1039-1047

[2] The Selectivity of Receptor Tyrosine Kinase Signaling Is Controlled by a Secondary SH2 Domain Binding Site [J].

Bae, Jae Hyun ;

Lew, Erin Denise ;

Yuzawa, Satoru ;

Tome, Francisco ;

Lax, Irit ;

Schlessinger, Joseph .

CELL, 2009, 138 (03) :514-524

[3] DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation [J].

Bakkenist, CJ ;

Kastan, MB .

NATURE, 2003, 421 (6922) :499-506

[4] Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2 [J].

Bassermann, F. ;

Pagano, M. .

CELL DEATH AND DIFFERENTIATION, 2010, 17 (01) :78-85

[5] A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling [J].

Bianchi, Katiuscia ;

Meier, Pascal .

MOLECULAR CELL, 2009, 36 (05) :736-742

[6] Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [J].

Bienko, M ;

Green, CM ;

Crosetto, N ;

Rudolf, F ;

Zapart, G ;

Coull, B ;

Kannouche, P ;

Wider, G ;

Peter, M ;

Lehmann, AR ;

Hofmann, K ;

Dikic, I .

SCIENCE, 2005, 310 (5755) :1821-1824

[7] Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination [J].

Bienko, Marzena ;

Green, Catherine M. ;

Sabbioneda, Simone ;

Crosetto, Nicola ;

Matic, Ivan ;

Hibbert, Richard G. ;

Begovic, Tihana ;

Niimi, Atsuko ;

Mann, Matthias ;

Lehmann, Alan R. ;

Dikic, Ivan .

MOLECULAR CELL, 2010, 37 (03) :396-407

[8] The molecular architecture of the TNF superfamily [J].

Bodmer, JL ;

Schneider, P ;

Tschopp, J .

TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (01) :19-26

[9] Prolyl hydroxylases as regulators of cell metabolism [J].

Boulahbel, Houda ;

Duran, Raul V. ;

Gottlieb, Eyal .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2009, 37 :291-294

[10] A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination [J].

Brzovic, PS ;

Lissounov, A ;

Christensen, DE ;

Hoyt, DW ;

Klevit, RE .

MOLECULAR CELL, 2006, 21 (06) :873-880

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