Regulation of antiviral CD8+ T cells by inhibitory natural killer cell receptors

被引：11

作者：

Byers, AM ^{[1
]}

Kemball, CC ^{[1
]}

Andrews, NP ^{[1
]}

Lukacher, AE ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

来源：

MICROBES AND INFECTION | 2003年 / 5卷 / 02期

关键词：

CD8(+) T-lymphocyte; viruses; killer cells; natural; T-cell receptor;

D O I：

10.1016/S1286-4579(02)00086-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent evidence indicates that CD8(+) T cells express natural killer cell receptors that constrain the range and magnitude of their activities. For virus-specific CD8(+) T cells, upregulation of these receptors serves to control infection, while concurrently minimizing bystander pathology. Dysregulated expression of these receptors, however, may foster the establishment of persistent virus infection. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：169 / 177

页数：9

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