Galectin-3 in acute coronary syndrome

被引：93

作者：

Agnello, Luisa ^{[1
]}

Bivona, Giulia ^{[1
]}

Lo Sasso, Bruna ^{[1
]}

Scazzone, Concetta ^{[1
]}

Bazan, Viviana ^{[2
]}

Bellia, Chiara ^{[1
]}

Ciaccio, Marcello ^{[1
,3
]}

机构：

[1] Univ Palermo, Dipartimento Biopatol & Biotecnol Med, Sez Biochim Clin & Med Mol Clin, Palermo, Italy

[2] Univ Palermo, Dipartimento Discipline Chirurg Oncol & Stomatol, Palermo, Italy

[3] AOUP P Giaccone, CoreLab, UOC Med Lab, Palermo, Italy

来源：

CLINICAL BIOCHEMISTRY | 2017年 / 50卷 / 13-14期

关键词：

Galectin-3; Acute coronary syndrome; Myocardial infarction; AMI; Prognosis; Heart failure; 2013 ACCF/AHA GUIDELINE; ASSOCIATION TASK-FORCE; MYOCARDIAL-INFARCTION; HEART-FAILURE; ARTERY-DISEASE; INHIBITION; EXPRESSION; MARKER; INFLAMMATION; DYSFUNCTION;

D O I：

10.1016/j.clinbiochem.2017.04.018

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Acute coronary syndrome (ACS) is a very common cause of hospitalizations worldwide each year. In the past decades biomarkers have become an indispensable tool for diagnosis, risk stratification and prognosis of cardiovascular disease, including ACS. Despite Troponin is considered the gold standard in diagnosis of ACS, several molecules have been investigated to identify predictive biomarkers of prognosis. Among these, Gal-3 has emerged as a promising prognostic marker. It has a pivotal role in inflammation and fibrosis. Both experimental and clinical studies have shown Gal-3 is an independent predictor of all-cause mortality, cardiovascular death and occurrence of HF following ACS. This article reviews the literature data regarding the role of Galectin-3 in ACS setting.

引用

页码：797 / 803

页数：7

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