Small peptides do not inhibit human non-pancreatic secretory phospholipase-A2 (type IIA)

被引：2

作者：

Clark, CI ^{[1
]}

Reid, RC ^{[1
]}

McGeary, RP ^{[1
]}

Schafer, K ^{[1
]}

Fairlie, DP ^{[1
]}

机构：

[1] Univ Queensland, Ctr Drug Design & Dev, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 274卷 / 03期

关键词：

antiflammins; phospholipase A(2); enzyme inhibitor; phospholipid;

D O I：

10.1006/bbrc.2000.3221

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven small peptides, that are among the most potent reported inhibitors of secreted mammalian phospholipases A(2), were found not to inhibit processing of a small phospholipid substrate by human nonpancreatic secretory phospholipase A(2) (type IIa), under conditions where certain non-peptides are potent inhibitors at nanomolar concentrations. (C) 2000 Academic Press.

引用

页码：831 / 834

页数：4

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