Harnessing bioinformatics to discover new vaccines

被引：124

作者：

Davies, Matthew N. ^{[1
]}

Flower, Darren R. ^{[1
]}

机构：

[1] Univ Oxford, Jenner Inst, Compton RG20 7NN, Berks, England

来源：

DRUG DISCOVERY TODAY | 2007年 / 12卷 / 9-10期

关键词：

D O I：

10.1016/j.drudis.2007.03.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.

引用

页码：389 / 395

页数：7

共 68 条

[1] Prediction of residues in discontinuous B-cell epitopes using protein 3D structures [J].

Andersen, Pernille Haste ;

Nielsen, Morten ;

Lund, Ole .

PROTEIN SCIENCE, 2006, 15 (11) :2558-2567

[2] Induction of immune responses by DNA vaccines in large animals [J].

Babiuk, LA ;

Pontarollo, R ;

Babiuk, S ;

Loehr, B ;

Little-van den Hurk, SV .

VACCINE, 2003, 21 (7-8) :649-658

[3] Nucleic acid vaccines: research tool or commercial reality [J].

Babiuk, LA ;

Babiuk, SL ;

Loehr, BI ;

Littel-van den Hurk, SV .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2000, 76 (1-2) :1-23

[4]

Bateman A, 2002, NUCLEIC ACIDS RES, V30, P276, DOI [10.1093/nar/gkr1065, 10.1093/nar/gkp985, 10.1093/nar/gkh121]

[5] Benchmarking B cell epitope prediction: Underperformance of existing methods [J].

Blythe, MJ ;

Flower, DR .

PROTEIN SCIENCE, 2005, 14 (01) :246-248

[6] Innate immune responses induced by classes of CpG oligodeoxynucleotides in ovine lymph node and blood mononuclear cells [J].

Booth, Jayaum S. ;

Nichani, Anil K. ;

Benjamin, Ponn ;

Dar, Arshud ;

Krieg, Arthur M. ;

Babiuk, Lorne A. ;

Mutwiri, George K. .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2007, 115 (1-2) :24-34

[7] Allergen immunotherapy: Therapeutic vaccines for allergic diseases - A WHO position paper [J].

Bousquet, J ;

Lockey, R ;

Malling, HJ .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 102 (04) :558-562

[8] Predicting protein subcellular locations using hierarchical ensemble of Bayesian classifiers based on Markov chains [J].

Bulashevska, Alla ;

Eils, Roland .

BMC BIOINFORMATICS, 2006, 7 (1)

[9] Predictive Bayesian neural network models of MHC class II peptide binding [J].

Burden, FR ;

Winkler, DA .

JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2005, 23 (06) :481-489

[10] A small peptide (CEL-1000) derived from the β-chain of the human major histocompatibility complex class II molecule induces complete protection against malaria in an antigen-independent manner [J].

Charoenvit, Y ;

Brice, GT ;

Bacon, D ;

Majam, V ;

Williams, J ;

Abot, E ;

Ganeshan, H ;

Sedegah, M ;

Doolan, DL ;

Carucci, DJ ;

Zimmerman, DH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (07) :2455-2463

← 1 2 3 4 5 6 7 →