Harnessing bioinformatics to discover new vaccines

被引：124

作者：

Davies, Matthew N. ^{[1
]}

Flower, Darren R. ^{[1
]}

机构：

[1] Univ Oxford, Jenner Inst, Compton RG20 7NN, Berks, England

来源：

DRUG DISCOVERY TODAY | 2007年 / 12卷 / 9-10期

关键词：

D O I：

10.1016/j.drudis.2007.03.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.

引用

页码：389 / 395

页数：7

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