Serum complement sensitivity as a key factor in Lyme disease ecology

被引：240

作者：

Kurtenbach, K

Sewell, HS

Ogden, NH

Randolph, SE

Nuttall, PA

机构：

[1] Univ Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 3PS, England

[2] NERC, Inst Virol & Environm Microbiol, Oxford OX1 3SR, England

[3] Univ Liverpool, Fac Vet Sci, Dept Vet Clin Med, Liverpool L69 3BX, Merseyside, England

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 03期

关键词：

D O I：

10.1128/IAI.66.3.1248-1251.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The sensitivity of Borrelia burgdorferi sensu late to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum and Borrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu late, suggesting a key role of complement in the global ecology of Lyme borreliosis.

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页码：1248 / 1251

页数：4

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