Spindle assembly in animal cells

被引：227

作者：

Compton, DA ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2000年 / 69卷

关键词：

mitosis; meiosis; microtubule; centrosome; chromosome; kinetochore;

D O I：

10.1146/annurev.biochem.69.1.95

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromosome segregation during mitosis and meiosis is driven by a complex superstructure called the spindle. Microtubules are the primary structural component of spindles, and spindle assembly and function are intimately linked to the intrinsic dynamics of microtubules. This review summarizes spindle structure and highlights recent findings regarding the mechanisms and molecules involved in organizing microtubules into spindles. In addition, mechanisms for chromosome movement and segregation are discussed.

引用

页码：95 / 114

页数：20

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