The RAF proteins take centre stage

被引：914

作者：

Wellbrock, C

Karasarides, M

Marais, R

机构：

[1] Inst Canc Res, Signal Transduct Team, Canc Res UK Ctr Cell & Mol Biol, London SW3 6JB, England

[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 11期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrm1498

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since their discovery over 20 years ago, the RAF proteins have been intensely studied. For most of that time, the focus of the field has been the C-RAF isoform and its role as an effector of the RAS proteins. However, a report that implicates B-RAF in human cancer has highlighted the importance of all members of this protein kinase family and recent studies have uncovered intriguing new data relating to their complex regulation and biological functions.

引用

收藏

页码：875 / 885

页数：11

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