In vitro inhibition of SARS virus replication by human Interferons

被引：27

作者：

Dahl, H

Linde, A

Strannegård, Ö

机构：

[1] Swedish Inst Infect Dis Control, Stockholm, Sweden

[2] Univ Gothenburg, Dept Clin Virol, Gothenburg, Sweden

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2004年 / 36卷 / 11-12期

关键词：

D O I：

10.1080/00365540410021144

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.

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页码：829 / 831

页数：3

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