Peripheral NK cell phenotypes: multiple changing of faces of an adapting, developing cell

被引：41

作者：

Perussia, B ^{[1
]}

Chen, YY ^{[1
]}

Loza, MJ ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA

来源：

MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 04期

关键词：

NK cells; cytokines; proliferation; differentiation;

D O I：

10.1016/j.molimm.2004.07.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have defined the existence of developmental relationships among human peripheral NK cells with distinct phenotypic and functional characteristics. These findings closely parallel the changes that occur in vivo during NK cell development, and in vitro in experimental culture systems supporting NK cell generation from hematopoietic progenitors. These new insights provide a simplified framework to understand NK cell immunobiology and the cellular bases for their roles in innate immunity, initiation and maintenance of immune responses via regulation of adaptive and accessory cell functions, and immune pathologies. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：385 / 395

页数：11

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