G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus

被引：65

作者：

MacDonald, John F. ^{[1
]}

Jackson, Michael F. ^{[1
]}

Beazely, Michael A. ^{[1
]}

机构：

[1] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2007年 / 1768卷 / 04期

关键词：

NNMDA receptor; G-protein coupled receptor; PKA; PKC; Stc kinases; synaptic efficacy; longterm potentiation;

D O I：

10.1016/j.bbamem.2006.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-term potentiation (LTP) and long-term depression (LTD) are the major forms of functional synaptic plasticity observed at CA1 synapses of the hippocampus. The balance between LTP and LTD or "metaplasticity" is controlled by G-protein coupled receptors (GPCRs) whose signal pathways target the N-methyl-D-asparate (NMDA) subtype of excitatory glutamate receptor. We discuss the protein kinase signal cascades stimulated by G alpha q and G alpha s coupled GPCRs and describe how control of NMDAR activity shifts the threshold for the induction of LTP. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：941 / 951

页数：11

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