Two hydrolase resistant analogues of diadenosine 5′,5"′-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein

被引：12

作者：

Blackburn, GM ^{[1
]}

Liu, XH

Rösler, A

Brenner, C

机构：

[1] Univ Sheffield, Dept Chem, Krebs Inst, Sheffield S3 7HF, S Yorkshire, England

[2] Thomas Jefferson Univ, Kimmel Canc Inst, Philadelphia, PA 19107 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 1-3期

关键词：

D O I：

10.1080/07328319808005178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The design and synthesis of analogues of diadenosine 5',5'''-P-1,P-3-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their role in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap(3)A binding/cleaving protein.

引用

页码：301 / 308

页数：8

共 25 条

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