Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease

被引：133

作者：

Siebner, HR ^{[1
]}

Rossmeier, C ^{[1
]}

Mentschel, C ^{[1
]}

Peinemann, A ^{[1
]}

Conrad, B ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2000年 / 178卷 / 02期

关键词：

Parkinson's disease; motor cortex; repetitive transcranial magnetic stimulation;

D O I：

10.1016/S0022-510X(00)00370-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ten unmedicated patients with Parkinson's disease received sub-threshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area (M1(HAND)) contralaterally to the more affected upper limb. Compared to a midfrontal sham-rTMS, real-rTMS over M1(HAND) was associated with a significant decrease in the global motor UPDRS score 1 h after the cessation of rTMS. This was mainly due to a clinical improvement in the arm contralaterally to the stimulated M1(HAND). These preliminary data suggest that focal rTMS of M1(HAND) may have a therapeutic potential in PD. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：91 / 94

页数：4

共 11 条

[1] Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].

Chen, R ;

Classen, J ;

Gerloff, C ;

Celnik, P ;

Wassermann, EM ;

Hallett, M ;

Cohen, LG .

NEUROLOGY, 1997, 48 (05) :1398-1403

[2] Simultaneous repetitive transcranial magnetic stimulation does not speed fine movement in PD [J].

Ghabra, MB ;

Hallett, M ;

Wassermann, EM .

NEUROLOGY, 1999, 52 (04) :768-770

[3] ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

[4]

MARSDEN CD, 1994, BRAIN, V117, P1383

[5]

PASCUALLEONE A, 1995, NEUROLOGY, V45, pA315

[6] Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression [J].

PascualLeone, A ;

Rubio, B ;

Pallardo, F ;

Catala, MD .

LANCET, 1996, 348 (9022) :233-237

[7] RESPONSES TO RAPID-RATE TRANSCRANIAL MAGNETIC STIMULATION OF THE HUMAN MOTOR CORTEX [J].

PASCUALLEONE, A ;

VALLSSOLE, J ;

WASSERMANN, EM ;

HALLETT, M .

BRAIN, 1994, 117 :847-858

[8] AKINESIA IN PARKINSONS-DISEASE .2. EFFECTS OF SUBTHRESHOLD REPETITIVE TRANSCRANIAL MOTOR CORTEX STIMULATION [J].

PASCUALLEONE, A ;

VALLSSOLE, J ;

BRASILNETO, JP ;

CAMMAROTA, A ;

GRAFMAN, J ;

HALLETT, M .

NEUROLOGY, 1994, 44 (05) :892-898

[9] Lasting cortical activation after repetitive TMS of the motor cortex - A glucose metabolic study [J].

Siebner, HR ;

Peller, M ;

Willoch, F ;

Minoshima, S ;

Boecker, H ;

Auer, C ;

Drzezga, A ;

Conrad, B ;

Bartenstein, P .

NEUROLOGY, 2000, 54 (04) :956-963

[10] Repetitive transcranial magnetic stimulation has a beneficial effect on bradykinesia in Parkinson's disease [J].

Siebner, HR ;

Mentschel, C ;

Auer, C ;

Conrad, B .

NEUROREPORT, 1999, 10 (03) :589-594

← 1 2 →