Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity

被引：47

作者：

Li, YS

Ishibashi, M

Satake, M

Chen, XG

Oshima, Y

Ohizumi, Y ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol Mol Biol, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Chiba Univ, Grad Sch Pharmaceut Sci, Dept Nat Prod Chem, Inage Ku, Chiba 2638522, Japan

[3] Tohoku Univ, Grad Sch Life Sci, Bioorgan Chem Lab, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 05期

关键词：

D O I：

10.1021/np020577p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sterols, stigmast-5-ene 3beta,4beta,7alpha,22alpha-tetraol (1) and stigmast-5-ene 3beta,7alpha,22alpha-triol (2), were isolated from the aerial parts of a Paraguayan medicinal plant, Verbena littoralis, together with the known compounds ursolic acid (3) and oleanolic acid (4). The structures of 1 and 2 were elucidated by spectroscopic analyses. Compounds 2-4 showed an enhancing activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells.

引用

收藏

页码：696 / 698

页数：3

相关论文

共 10 条

[1] IDENTIFICATION OF C-22 EPIMERS IN STEROIDS BY C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].

LETOURNEUX, Y ;

KHUONGHUU, Q ;

GUT, M ;

LUKACS, G .

JOURNAL OF ORGANIC CHEMISTRY, 1975, 40 (11) :1674-1675

[2] Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells [J].

Li, P ;

Matsunaga, K ;

Yamamoto, K ;

Yoshikawa, R ;

Kawashima, K ;

Ohizumi, Y .

NEUROSCIENCE LETTERS, 1999, 273 (01) :53-56

[3] Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells [J].

Li, YS ;

Matsunaga, K ;

Kato, R ;

Ohizumi, Y .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2001, 53 (06) :915-919

[4] Verbenachalcone, a novel dimeric dihydrochalcone with potentiating activity on nerve growth factor-action from Verbena littoralis [J].

Li, YS ;

Matsunaga, K ;

Kato, R ;

Ohizumi, Y .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (06) :806-808

[5] Littoralisone, a novel neuritogenic iridolactone having an unprecedented heptacyclic skeleton including four- and nine-membered rings consisting of glucose from Verbena littoralis [J].

Li, YS ;

Matsunaga, K ;

Ishibashi, M ;

Ohizumi, Y .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (06) :2165-2167

[6]

MAURIZIO B, 1987, PHYTOCHEMISTRY, V26, P497

[7] Antineoplastic agents. 428 - Synthesis of the marine sponge cycloheptapeptide phakellistatin 5 [J].

Pettit, GR ;

Toki, BE ;

Xu, JP ;

Brune, DC .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (01) :22-28

[8]

SEILER N, 1966, Z NATURFORSCH PT B, VB 21, P78

[9] TRITERPENOID SAPONINS FROM PLANTS OF ARALIACEAE [J].

SRIVASTAVA, SK ;

JAIN, DC .

PHYTOCHEMISTRY, 1989, 28 (02) :644-647

[10]

UMANA E, 1990, International Journal of Crude Drug Research, V28, P175