A structural basis for complement inhibition by Staphylococcus aureus

被引：136

作者：

Hammel, Michal

Sfyroera, Georgia

Ricklin, Daniel

Magotti, Paola

Lambris, John D.

Geisbrecht, Brian V. ^{[1
]}

机构：

[1] Univ Missouri, Div Cell Biol & Biophys, Sch Biol Sci, Kansas City, MO 64110 USA

[2] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

NATURE IMMUNOLOGY | 2007年 / 8卷 / 04期

关键词：

D O I：

10.1038/ni1450

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-angstrom structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein ( Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-angstrom structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.

引用

收藏

页码：430 / 437

页数：8

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