Heparin-induced thrombocytopenia

被引：320

作者：

Arepally, Gowthami M. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Div Hematol, Durham, NC USA

来源：

BLOOD | 2017年 / 129卷 / 21期

基金：

美国国家卫生研究院;

关键词：

MOLECULAR-WEIGHT HEPARIN; FACTOR 4/HEPARIN ANTIBODIES; PLATELET-AGGREGATION TEST; TISSUE FACTOR EXPRESSION; UNFRACTIONATED HEPARIN; CARDIOPULMONARY BYPASS; THROMBOEMBOLIC COMPLICATIONS; WARFARIN THROMBOPROPHYLAXIS; ANTITHROMBOTIC PROPHYLAXIS; CONFORMATIONAL-CHANGES;

D O I：

10.1182/blood-2016-11-709873

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular Fc gamma RIIA on platelets and monocytes to propagate ahypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti-PF4/and laboratory findings have also been recently harnessed for disease prevention. This review will summarize our current understanding of HIT by reviewing pathogenesis, essential clinical and laboratory features, and management.

引用

收藏

页码：2864 / 2872

页数：9

相关论文

共 131 条

[91] Effect of fondaparinux on platelet activation in the presence of heparin-dependent antibodies: a blinded comparative multicenter study with unfractionated heparin [J].

Savi, P ;

Chong, BH ;

Greinacher, A ;

Gruel, Y ;

Kelton, JG ;

Warkentin, TE ;

Eichler, P ;

Meuleman, D ;

Petitou, M ;

Herault, JP ;

Cariou, R ;

Herbert, JM .

BLOOD, 2005, 105 (01) :139-144

[92] Frequent off-label use of fondaparinux in patients with suspected acute heparin-induced thrombocytopenia (HIT) - findings from the GerHIT multi-centre registry study [J].

Schindewolf, Marc ;

Steindl, Julia ;

Beyer-Westendorf, Jan ;

Schellong, Sebastian ;

Dohmen, Pascal Maria ;

Brachmann, Johannes ;

Madlener, Katharina ;

Poetzsch, Bernd ;

Klamroth, Robert ;

Hankowitz, Johannes ;

Banik, Norbert ;

Eberle, Sonja ;

Kropff, Stefan ;

Mueller, Markus Michael ;

Lindhoff-Last, Edelgard .

THROMBOSIS RESEARCH, 2014, 134 (01) :29-35

[93] Studies of the anti-platelet factor 4/heparin immune response: adapting the enzyme-linked immunosorbent spot assay for detection of memory B cells against complex antigens [J].

Selleng, Kathleen ;

Schuett, Antje ;

Selleng, Sixten ;

Warkentin, Theodore E. ;

Greinacher, Andreas .

TRANSFUSION, 2010, 50 (01) :32-39

[94] New Oral Anticoagulants in the Treatment of Heparin-Induced Thrombocytopenia [J].

Sharifi, Mohsen ;

Bay, Curt ;

Vajo, Zoltan ;

Freeman, Wilbur ;

Sharifi, Mirali ;

Schwartz, Frederic .

THROMBOSIS RESEARCH, 2015, 135 (04) :607-609

[95]

SHERIDAN D, 1986, BLOOD, V67, P27

[96] The incidence of recognized heparin-induced thrombocytopenia in a large, tertiary care teaching hospital [J].

Smythe, Maureen A. ;

Koerber, John M. ;

Mattson, Joan C. .

CHEST, 2007, 131 (06) :1644-1649

[97] Incidence of Thrombocytopenia in Hospitalized Patients with Venous Thromboembolism [J].

Stein, Paul D. ;

Hull, Russell D. ;

Matta, Fadi ;

Yaekoub, Abdo Y. ;

Liang, Jane .

AMERICAN JOURNAL OF MEDICINE, 2009, 122 (10) :919-930

[98] Diagnostic accuracy of rapid immunoassays for heparin-induced thrombocytopenia A systematic review and meta-analysis [J].

Sun, Lova ;

Gimotty, Phyllis A. ;

Lakshmanan, Suvasini ;

Cuker, Adam .

THROMBOSIS AND HAEMOSTASIS, 2016, 115 (05) :1044-1055

[99] Determinants of PF4/heparin immunogenicity [J].

Suvarna, Shayela ;

Espinasse, Benjamin ;

Qi, Rui ;

Lubica, Rauova ;

Poncz, Mortimer ;

Cines, Douglas B. ;

Wiesner, Mark R. ;

Arepally, Gowthami M. .

BLOOD, 2007, 110 (13) :4253-4260

[100]

TEO C P, 1989, Annals Academy of Medicine Singapore, V18, P379

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