Heparin-induced thrombocytopenia

被引:320
作者
Arepally, Gowthami M. [1 ]
机构
[1] Duke Univ, Med Ctr, Div Hematol, Durham, NC USA
基金
美国国家卫生研究院;
关键词
MOLECULAR-WEIGHT HEPARIN; FACTOR 4/HEPARIN ANTIBODIES; PLATELET-AGGREGATION TEST; TISSUE FACTOR EXPRESSION; UNFRACTIONATED HEPARIN; CARDIOPULMONARY BYPASS; THROMBOEMBOLIC COMPLICATIONS; WARFARIN THROMBOPROPHYLAXIS; ANTITHROMBOTIC PROPHYLAXIS; CONFORMATIONAL-CHANGES;
D O I
10.1182/blood-2016-11-709873
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular Fc gamma RIIA on platelets and monocytes to propagate ahypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti-PF4/and laboratory findings have also been recently harnessed for disease prevention. This review will summarize our current understanding of HIT by reviewing pathogenesis, essential clinical and laboratory features, and management.
引用
收藏
页码:2864 / 2872
页数:9
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