mTOR inhibitor rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice

被引：41

作者：

Hou, Guiqin ^{[2
]}

Zhang, Qi ^{[2
]}

Wang, Lili ^{[1
]}

Liu, Mingyue ^{[3
]}

Wang, Jianren ^{[4
]}

Xue, Lexun ^{[1
]}

机构：

[1] Zhengzhou Univ, Cell Biol Lab, Dept Biol, Zhengzhou 450001, Henan, Peoples R China

[2] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China

[3] Peoples Hosp Henan Prov, Zhengzhou 450003, Peoples R China

[4] Henan Univ Tradit Chinese Med, Dept Physiol, Zhengzhou 450008, Peoples R China

来源：

CANCER LETTERS | 2010年 / 290卷 / 02期

关键词：

Apoptosis; Esophageal squamous cell carcinoma (ESCC); mTOR; Rapamycin; Signaling pathway; MAMMALIAN TARGET; SIGNALING PATHWAY; CANCER-THERAPY; PROSTATE-CANCER; PTEN; AKT; ACTIVATION; EXPRESSION; PROLIFERATION; APOPTOSIS;

D O I：

10.1016/j.canlet.2009.09.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Accumulating evidences have demonstrated that mTOR pathway has a central role not only in cell growth but also in invasion and metastasis of cancers. Here we reported that rapamycin or cisplatin alone inhibited significantly the tumor growth and their combination had the strongest anticancer effect on transplantable tumor growth of human ESCC cell line EC9706 in nude mice. Furthermore, western blots, RT-PCR and TUNEL assay revealed that rapamycin specifically blocked mTOR pathway and induced apoptosis of ESCC cells in vivo. These findings indicate a rationale for using mTOR inhibitors as a mechanism-based therapeutic approach to patients with ESCC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：248 / 254

页数：7

共 36 条

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