The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors

被引:76
作者
Hildbrand, P
Cirulli, V
Prinsen, RC
Smith, KA
Torbett, BE
Salomon, DR
Crisa, L
机构
[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA
关键词
D O I
10.1182/blood-2003-12-4219
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Circulating endothelial progenitors contribute to neovascularization at sites of injury and tumorigenesis in postnatal life. Yet, the molecular mechanisms initiating the endothelial developmental program of these precursors remain elusive. Here we provide evidence that endothelial development from progenitors circulating in human cord blood requires angiopoietins, a set of growth factors also involved in vascular branching during embryogenesis. We show that cord blood cells with the potential for endothelial development reside in a CD34(+)CD11b(+) subset capable of autonomously producing and binding angiopoietins. Functionally, endogenous angiopoietin-1 regulates initial endothelial cell commitment, whereas angiopoietin-2 enhances expansion of the endothelial cell progeny. These findings suggest a role for angiopoietins as regulators of endothelial development from circulating progenitors and imply a function of angiopoietins at distinct developmental steps in postnatal angiogenesis. (C) 2004 by The American Society of Hematology.
引用
收藏
页码:2010 / 2019
页数:10
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