Effects of N-methyl-D-aspartate receptor subunit antagonists on regulation of susceptibility to audiogenic seizures in rats

被引：11

作者：

Hironaka, N ^{[1
]}

Niki, H ^{[1
]}

机构：

[1] RIKEN, Brain Sci Inst, Lab Neurobiol Emot, Wako, Saitama 3510198, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 288卷 / 02期

关键词：

audiogenic seizure; priming; N-methyl-D-aspartate; NR2B; ifenprodil; dextromethorphan; rat;

D O I：

10.1016/S0304-3940(00)01219-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats become susceptible to audiogenic seizures (AS) when they are exposed to intense noise during a certain critical period of development (priming). Antagonism of N-methyl-D-aspartate (NMDA) receptor NR2B subunit by injecting an antagonist ifenprodil at priming enhanced the later susceptibility to AS. An weak NR2A antagonist, dextromethorphan, did not show such effects while it significantly suppressed the manifestation of AS in already susceptible post-weaning (primed) rats. These results indicate that NR2B plays an important role in the developmental regulation of the auditory system involved in AS but this subunit has a minor relevance to the manifestation of AS in the later life. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：139 / 142

页数：4

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