ENHANCED SUSCEPTIBILITY OF AUDIOGENIC-SEIZURES IN FYN-KINASE DEFICIENT MICE

被引：40

作者：

MIYAKAWA, T

YAGI, T

TANIGUCHI, M

MATSUURA, H

TATEISHI, K

NIKI, H

机构：

[1] UNIV TOKYO,FAC LETTERS,DEPT PSYCHOL,BUNKYO KU,TOKYO 113,JAPAN

[2] NATL INST PHYSIOL SCI,DEPT NEUROBIOL & BEHAV GENET,OKAZAKI,AICHI 444,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1995年 / 28卷 / 02期

关键词：

FYN TYROSINE KINASE; MUTANT MOUSE; GENE TARGETING; AUDIOGENIC SEIZURE; ACOUSTIC PRIMING; WILD RUNNING; CLONIC TONIC CONVULSION;

D O I：

10.1016/0169-328X(94)00251-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mice with a mutation in fyn genes were examined for their susceptibility to acoustically primed audiogenic seizures. Homozygous mutant (fyn(z)/fyn(z)) mice were significantly more likely to have seizures and to show the stronger seizure syndrome (clonus). These results indicate that the susceptibility of acoustically primed audiogenic seizures is enhanced in the Fyn kinase deficient mice.

引用

页码：349 / 352

页数：4

共 21 条

[1]

CHAUVEL P, 1980, NEUROLOGICAL MUTATIO, P513

[2]

FREUND RJ, 1993, STATISTICAL METHODS

[3]

FULLER J L, 1968, Developmental Psychobiology, V1, P185, DOI 10.1002/dev.420010306

[4] IMPAIRED LONG-TERM POTENTIATION, SPATIAL-LEARNING, AND HIPPOCAMPAL DEVELOPMENT IN FYN MUTANT MICE [J].