INCREASED FEARFULNESS OF FYN TYROSINE KINASE DEFICIENT MICE

被引：74

作者：

MIYAKAWA, T

YAGI, T

WATANABE, S

NIKI, H

机构：

[1] UNIV TOKYO,FAC LETTERS,DEPT PSYCHOL,BUNKYO KU,TOKYO 113,JAPAN

[2] NATL INST PHYSIOL SCI,DEPT NEUROBIOL & BEHAV GENET,OKAZAKI,AICHI 444,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 27卷 / 01期

关键词：

FYN KINASE-DEFICIENT MOUSE; INCREASED FEARFULNESS; EMOTIONALITY; NOVELTY PREFERENCE; LIGHT AVERSION; PASSIVE AVOIDANCE; MUTANT MOUSE; POLYMERASE CHAIN REACTION;

D O I：

10.1016/0169-328X(94)90201-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fyn-deficient mice were produced by inserting the beta-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fyn(Z)/fyn(Z)) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fyn(Z)) mice. These results indicate that fyn(Z)/fyn(Z) mice are hyperresponsive to fear-inducing stimuli.

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页码：179 / 182

页数：4

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