Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

被引：41

作者：

He, WD

Cik, M

Lesage, A

Van der Linden, I

De Kimpe, N

Appendino, G

Bracke, J

Mathenge, SG

Mudida, FP

Leysen, JE

Van Puyvelde, L

机构：

[1] State Univ Ghent, Fac Agr & Appl BIol Sci, Dept Organ Chem, B-9000 Ghent, Belgium

[2] Janssen Res Fdn, Dept Biochem Pharmacol, B-2340 Beerse, Belgium

[3] Univ Turin, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy

[4] Janssen Res Fdn, Dept Analyt Med Chem, B-2340 Beerse, Belgium

[5] Univ Nairobi, Dept Bot, Nairobi, Kenya

[6] TRAMEDA, Nairobi, Kenya

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 09期

关键词：

D O I：

10.1021/np000249u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.

引用

页码：1185 / 1187

页数：3

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